If you value this website, please consider donating to its maintenance. Summary Zinc is a nutritionally essential mineral needed for catalytic, structural, and regulatory functions in the body. Severe zinc deficiency is a rare, genetic or acquired condition. G6pd deficiency diet pdf zinc deficiency, often called marginal zinc deficiency, is quite common in the developing world, affecting an estimated 2 billion people.
Zinc deficiency can cause impaired growth and development in children, pregnancy complications, and immune dysfunction and increased susceptibility to infections. Zinc is an essential trace element for all forms of life. The significance of zinc in human nutrition and public health was recognized relatively recently. Function Numerous aspects of cellular metabolism are zinc-dependent. Zinc plays important roles in growth and development, the immune response, neurological function, and reproduction.
A finger-like structure, known as a zinc finger motif, stabilizes the structure of a number of proteins. High intake of zinc induces the intestinal synthesis of a copper-binding protein called metallothionein. Calcium High levels of dietary calcium impair zinc absorption in animals, but it is uncertain whether this occurs in humans. Vitamin A Zinc and vitamin A interact in several ways. Zinc is a component of retinol-binding protein, a protein necessary for transporting vitamin A in the blood.
Deficiency Severe zinc deficiency Much of what is known about severe zinc deficiency was derived from the study of individuals born with acrodermatitis enteropathica, a genetic disorder resulting from the impaired uptake and transport of zinc. Marginal zinc deficiency It is now recognized that milder zinc deficiency contributes to a number of health problems, especially common in children who live in developing countries. Biomarkers of zinc status Currently, there is not a sensitive and specific biomarker to detect zinc deficiency in humans. Infants, children, adolescents, and pregnant and lactating women are at increased risk of zinc deficiency.
Delayed neurological and behavioral development in young children Low maternal zinc nutritional status has been associated with diminished attention in newborn infants and poorer motor function at six months of age. Increased susceptibility to infectious disease in children Diarrhea: It is estimated that diarrheal diseases result in the deaths of over 1. Pneumonia: Zinc supplementation may also reduce the incidence of lower respiratory infections, such as pneumonia. However, the results of zinc supplementation trials on immune function in the elderly have been mixed. Despite numerous well-controlled trials, the efficacy of zinc lozenges in treating common cold symptoms remains questionable. The physiological basis for a beneficial effect of high-dose zinc supplementation on cold symptoms is not well understood. However, the HIV virus also requires zinc, and excessive zinc intake may stimulate the progression of HIV infection.